Monoclonal Antibody to FOXO1 (Clone: ABM4E66)

Size

£319.00

SKU:: 10-4163
Additional Names:: FOXO1||FKHR||FOXO1A
Purification:: Protein G Chromatography
Supplier:: Abeomics Inc.
Host:: Mouse
Reactivities:: Human
Clone:: ABM4E66
Uniprot:: Q12778
Gene Details:: FOXO1
Extra Details:: FOXO1 is one of the fox proteins playing pivotal roles in several human intracellular pathways. These proteins are transcription factors acting as nuclear regulator of transcriptional activity of a number of metabolic processes such as the cellular response to oxidative stress. FOXO1 protein response to oxidative stress may be linked to Alzheimer's disease (AD) by means of insulin brain resistance. FOXO1 plays a critical role in establishing and maintaining the B cell specific differentiation program, but it is also responsible for cell death due to an inappropriate BCR signaling. This protein is highly expressed in B cells, is downregulated in Hodgkin and Reed-Sternberg (HRS) cells of cHL (Classical Hodgkin Lymphoma).