Monoclonal antibody to CD161 (clone: ABM27F5)

Size

£319.00

SKU:: 10-4049
Additional Names:: Killer cell lectin-like receptor subfamily B member 1, C-type lectin domain family 5 member B, HNKR-P1a, NKR-P1A, Natural killer cell surface protein P1A, CD161
Purification:: Protein G Chromatography
Supplier:: Abeomics Inc.
Host:: Mouse
Reactivities:: Human
Clone:: ABM27F5
Uniprot:: Q12918
Gene Details:: KLRB1
Extra Details:: CD161 is the human equivalent of mouse NK cell receptor P1A. It is a type II transmembrane glycoprotein with characteristics of the C-type lectin superfamily. The expression confines to lymphocytes found in human gut and liver, as well as blood, especially NK (natural killer) cells, Th17 (T helper 17) cells, and a population of unconventional T cells known as MAIT (mucosal-associated invariant T) cells. CD161 promotes T cell expansion and eventually has been identified as a marker of human IL-17-producing T cells. It plays a pivotal role in trans-endothelial migration and is also implicated in the pathogenesis of RA (rheumatoid arthritis) as well as graft-versus-host disease (GVHD).