Monoclonal Antibody to CLEC9A (Clone: ABM23H8)

Size

£319.00

SKU:: 10-4020
Additional Names:: C-type lectin domain family 9 member A, CLEC9A
Purification:: Protein G Chromatography
Supplier:: Abeomics Inc.
Host:: Mouse
Reactivities:: Human
Clone:: ABM23H8
Uniprot:: Q6UXN8
Gene Details:: CLEC9A
Extra Details:: CLEC9A is a C-type lectin receptor involved in the sensing and presentation of antigens derived from necrotic cells. It is expressed on the surface of the mouse and human dendritic cell subsets specialized for the uptake and processing of material from dead cells. CLEC9A is expressed at the cell surface as a glycosylated dimer and can mediate endocytosis, but not phagocytosis. It possesses a cytoplasmic immunoreceptor tyrosine-based activation-like motif that can recruit Syk kinase and can induce proinflammatory cytokine production. CLEC9A provides targeted recruitment of the adaptive immune system during infection and can also be utilized to enhance immune responses generated by vaccines.