Monoclonal Antibody to Dectin-2 (Clone: ABM2H28)

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£319.00

SKU:: 10-4013
Additional Names:: CLEC6A||CLECSF10||DECTIN2
Purification:: Protein G Chromatography
Supplier:: Abeomics Inc.
Host:: Mouse
Reactivities:: Human, Mouse
Clone:: ABM2H28
Uniprot:: Q6EIG7
Gene Details:: CLEC6A
Extra Details:: Dectin-2 (C-type lectin domain family 6 member A) is a type II membrane receptor with an extracellular C-type lectin-like domain fold. Dectin-2 plays an important role in the host defense against C. albicans infection by inducing TH17 cell differentiation. It binds high-mannose carbohydrates in a Ca(2+)-dependent manner. In Dectin-2 glycosylation occurs at Asn131, Asn170. Dectin-2 has 2 isoforms produced by alternative splicing. Dectin-2 is strongly expressed in monocytes and weakly in B-cells and also expressed in spleen, tonsils, lymph node, lungs, leukocytes, dendritic cells and bone marrow.