YR0128
Human Integrin alpha 4 Monoclonal Antibody
Size
£355.00
- SKU:
- YR0128
- Additional Names:
- CD49D|IA4|ITGA4
- Application:
- ELISA, FuncS, Neutralisation
- Molecular Weight:
- 150 kDa
- Purity:
- >95%
- Storage Conditions:
- 2-8[o]C Avoid freeze/thaw cycles., -70[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Human Integrin alpha 4
- Formulation:
- Purified from cell culture supernatant in an animal-free facility
- Uniprot:
- P13612
- Synonyms:
- 269C wild type;alpha 4 subunit of VLA-4 receptor;antigen CD49D, alpha-4 subunit of VLA-4 receptor;CD49 antigen-like family member D;CD49D;IA4;integrin alpha-4;integrin alpha-IV;very late activation protein 4 receptor, alpha 4 subunit;VLA-4 subunit alpha
- Extra Details:
- Natalizumab is a monoclonal anti-integrin antibody which binds to the alpha 4 subunit of integrins to prevent migration of immune cells, and is used to treat Crohn's disease or multiple sclerosis.Humanized IgG4k monoclonal antibody produced in murine myeloma cells. Natalizumab contains human framework regions and the complementarity-determining regions of a murine antibody that binds to a4-integrin.Binds to the A Alpha4-subunit of A Alpha4b 1 and A Alpha4b 7 integrins expressed on the surface of all leukocytes except neutrophils, and inhibits the A Alpha4-mediated adhesion of leukocytes to their counter-receptor(s).
- Shipping Conditions:
- Blue Ice