Recombinant Human Asparaginyl endopeptidase/Legumain/LGMN Protein

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£459.00

Was £540.00

SKU:: RP03221LQ
Additional Names:: Asparaginyl Endopeptidase|Legumain|LGMN|Protease Cysteine 1|PRSC1
Molecular Weight:: 55-60 kDa
Purity:: ≥95%
Storage Conditions:: -70[o]C Aliquot. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Ile18-Tyr433
Formulation:: Recombinant Human Asparaginyl endopeptidase/Legumain/LGMN Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Ile18-Tyr433) of Human Asparaginyl endopeptidase/Legumain/LGMN (Accession #AAH03061.1) fused with His tag at the C-terminus.
Species:: Human
Synonyms:: AEP;asparaginyl endopeptidase;cysteine protease 1;legumain;LGMN1;protease, cysteine 1;protease, cysteine, 1 (legumain);PRSC1
Extra Details:: Legumain is a lysosomal cysteine protease which is a member of the peptidase C13 family. Though it is found in many tissues, it is highly expressed in the kidney, heart, and placenta. Legumain has a strict specificity for hydrolysis of asparaginyl bonds and can also cleave aspartyl bonds slowly, especially under acidic conditions. Over-expression Legumain in tumors is significant for invasion and metastasis. In addition, Legumain may be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system and negative regulation of neuron apoptosis.