RP03215LQ
Recombinant Human Pyruvate kinase PKM/PKM protein
Size
£135.15
Was £159.00
- SKU:
- RP03215LQ
- Additional Names:
- CTHBP|OIP-3|Pyruvate kinase PKM|THBP1
- Molecular Weight:
- 60 kda
- Purity:
- ≥95%
- Storage Conditions:
- -70[o]C Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Ser2-Pro531
- Formulation:
- Recombinant Human PKM2 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ser2-Pro531) of human PKM2 (Accession #NP_002645.3) fused with His tag at the N-terminus.
- Species:
- Human
- Uniprot:
- P14618
- Synonyms:
- CTHBP;cytosolic thyroid hormone-binding protein;epididymis secretory protein Li 30;HEL-S-30;OIP3;OPA-interacting protein 3;p58;PK, muscle type;PK3;PKM2;pyruvate kinase 2/3;pyruvate kinase isozymes M1/M2;pyruvate kinase muscle isozyme;pyruvate kinase PKM;pyruvate kinase, muscle;TCB;THBP1;thyroid hormone-binding protein 1;thyroid hormone-binding protein, cytosolic;tumor M2-PK
- Extra Details:
- Pyruvate kinase isoform M2 (PKM2) is a member of the pyruvate kinase (PK) family, a pivotal glycolytic enzyme that is consistently changed during tumorigenesis. PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets. As the rate-controlling enzyme in glycolysis, PKM2, has also been found to be expressed in embryonic, proliferating, and tumor cells, and it has been considered to be crucial for the metabolism and growth of tumor cells. Recent studies have shown that PKM2 promotes cell proliferation and suppresses cell apoptosis in various tumors. In addition, it has been reported that the PKM2 knockdown affects the Akt and ERK protein kinases.
- Shipping Conditions:
- Dry Ice