RP03183
Recombinant Human Gelsolin/GSN Protein
Size
£193.00
- SKU:
- RP03183
- Additional Names:
- Actin-depolymerizing factor|ADF|AGEL|Brevin|Gelsolin|GSN
- Molecular Weight:
- 115-125 KDa
- Purity:
- ≥90%
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Ala28-Ala782
- Formulation:
- Recombinant Human Gelsolin/GSN Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala28-Ala782) of Human Gelsolin/GSN (Accession #NP_000168.1) fused with mouse IgG1 Fc tag at the C-terminus.
- Species:
- Human
- Uniprot:
- P06396-1
- Synonyms:
- actin-depolymerizing factor;ADF;AGEL;brevin;epididymis secretory sperm binding protein;gelsolin
- Extra Details:
- Gelsolin is a calcium-activated actin filament severing and capping protein found in many cell types and as a secreted form in the plasma of vertebrates. Gelsolin is composed of six of these domains, termed G1-6. Some reaseraches show that gelsolin can act as a transcriptional cofactor in signal transduction and its own expression and function can be influenced by epigenetic changes. The difference in the expression levels of cytoplasmic and plasma gelsolin suggests that these two different forms of gelsolin may play different roles after cardiac injury. Plasma gelsolin, as an important component of the EASS, may have evolved to rapidly clear actin filaments from the circulation that are released by injured or dead cells.
- Shipping Conditions:
- Blue Ice