RP02986LQ
Recombinant Human Ezrin/EZR Protein
Size
£428.40
Was £504.00
- SKU:
- RP02986LQ
- Additional Names:
- Cytovillin|EZR|Ezrin|p81|VIL2|Villin-2
- Molecular Weight:
- 80 kDa
- Purity:
- ≥95%
- Storage Conditions:
- -70[o]C Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Met1-Leu586
- Formulation:
- Recombinant Human Ezrin/EZR Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Leu586) of human Ezrin/EZR (Accession #NP_001104547.1) fused with no additional amino acid.
- Species:
- Human
- Uniprot:
- P15311
- Synonyms:
- CVIL;CVL;Cytovillin;cytovillin 2;epididymis secretory protein Li 105;ezrin;HEL-S-105;p81;VIL2;villin 2 (ezrin);Villin-2
- Extra Details:
- Ezrin is expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. The N-terminus of ezrin contains a FERM domain which is further subdivided into three subdomains. The C-terminus contain a ERM domain. As a member of the ERM protein family, Ezrin serves as an intermediate between the plasma membrane and the actin cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization. Ezrin probably involved in connections of major cytoskeletal structures to the plasma membrane. The N-terminal FERM domain strongly binds sodium-hydrogen exchanger regulatory factor (NHERF) proteins (involving long-range allostery). The C-terminal binds to actin, phosphatidylinositol bis-phosphate (PIP2) and membrane proteins like CD44 and ICAM-2. In epithelial cells, Ezrin is required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, Ezrin is required for normal macropinocytosis.
- Shipping Conditions:
- Dry Ice