RP02928S
Recombinant Mouse IL-23/IL-12B&IL-23A Protein
Size
£193.00
- SKU:
- RP02928S
- Additional Names:
- Il-12b|Il-12p40|IL-23|IL12B|Il12p40|il23A|p19|p40
- Molecular Weight:
- 20-25 kDa(IL-23A) , 45-50 kDa(IL-12B)
- Purity:
- ≥90%
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Met23-Ser335&Ala21-Ala196
- Formulation:
- Recombinant Mouse IL-23/IL-12B&IL-23A Protein is produced by HEK293 expression system. The target protein is expressed with sequence (N-His(IL-23a)&No tag(IL-12b)) of mouse Met23-Ser335&Ala21-Ala196 (Accession #) fused with a 6xHis tag at the N-terminus(IL23A).
- Species:
- Mouse
- Sequence:
- MWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRS&AVPRSSSPDWAQCQQLSRNLCMLAWNAHAPAGHMNLLREEEDEETKNNVPRIQCEDGCDPQGLKDNSQFCLQRIRQGLAFYKHLLDSDIFKGEPALLPDSPMEQLHTSLLGLSQLLQPEDHPRETQQMPSLSSSQQWQRPLLRSKILRSLQAFLAIAARVFAHGAATLTEPLVPTA
- Uniprot:
- P43432, Q9EQ14
- Synonyms:
- CLMF p40;cytotoxic lymphocyte maturation factor 40 kDa subunit;IL-;Il-1;Il-12;IL-12 p40 subunit;IL-12 subunit p40;Il-12b;Il-12p40;IL-23;IL-23 subunit alpha;IL-23 subunit p40;IL-23-A;IL-23p19;Il12p40;interleukin-12 p40 subunit;interleukin-12 subunit beta;interleukin-23 subunit alpha;interleukin-23 subunit p19;p1;p19;p40
- Extra Details:
- Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1-5). The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Mouse p19 cDNA encodes a 196 amino acid residue (aa) precursor protein with a putative 19 aa signal peptide and 177 aa mature protein. Human and mouse p19 share 70% aa sequence identity. Although p19 is expressed by activated macrophages, dendritic cells, T?cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R). IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T?cells. While IL-12 acts on both na?ve and memory human Tnbsp;cells, the effects of IL-23 is restricted to memory Tcells. In mouse, IL-23 but not IL-12, has also been shown to induce memory T cells to secret IL-17, a potent proinflammatory cytokine. IL-12 and IL-23 can induce IL-12 production from mouse splenic DC of both the CD8- and CD8+ subtypes, however only IL-23 can act directly on CD8+ DC to mediate immunogenic presentation of poorly immunogenic tumor/self peptide.
- Shipping Conditions:
- Blue Ice