RP02855
Recombinant Human Complement C3 Protein
Size
£193.00
- SKU:
- RP02855
- Additional Names:
- C3, CPAMD1, Complement C3, Complement C3 beta chain
- Molecular Weight:
- 45-60,64-80,110-140 kDa
- Purity:
- ≥90%
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Ser23-Asn1663
- Formulation:
- Recombinant Human Complement C3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser23-Asn1663) of Human Complement C3 (Accession #NM_000064.4) fused with His tag at the C-Terminus.
- Species:
- Human
- Uniprot:
- P01024
- Synonyms:
- acylation-stimulating protein cleavage product;AHUS5;ARMD9;ASP;C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1;C3a;C3a anaphylatoxin;C3b;complement C3;complement component 3;complement component C3a;complement component C3b;CPAMD1;epididymis secretory sperm binding protein Li 62p;HEL-S-62p;prepro-C3
- Extra Details:
- C3 is the major complement component serum. It is mainly synthesized by macrophages and liver. C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. It is cleaved into two fragments, C3a and C3b. C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
- Shipping Conditions:
- Blue Ice