Recombinant Human Angiopoietin-like 8/ANGPTL8 (22-198) Protein

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£164.05

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SKU:: RP02831
Additional Names:: Angiopoietin-like protein 8|Angptl8|Betatrophin|Lipasin
Molecular Weight:: 54 kda
Purity:: ≥ 80 %
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Ala22-Ala198
Formulation:: Recombinant Human Angiopoietin-like 8/ANGPTL8(22-198) Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala22-Ala198) of human Angiopoietin-like 8/ANGPTL8 (Accession #NP_061157.3) fused with a hFc tag at the N-terminus.
Species:: Human
Sequence:: APMGGPELAQHEELTLLFHGTLQLGQALNGVYRTTEGRLTKARNSLGLYGRTIELLGQEVSRGRDAAQELRASLLETQMEEDILQLQAEATAEVLGEVAQAQKVLRDSVQRLEVQLRSAWLGPAYREFEVLKAHADKQSHILWALTGHVQRQRREMVAQQHRLRQIQERLHTAALPA
Uniprot:: Q6UXH0
Synonyms:: angiopoietin-like protein 8;Betatrophin;betatrophin variant 1;betatrophin variant 2;C19orf80;hepatocellular carcinoma-associated gene TD26;hepatocellular carcinoma-associated protein TD26;lipasin;PRO1185;PVPA599;refeeding-induced fat and liver protein;RIFL;TD26
Extra Details:: The protein specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. It promotes pancreatic beta cell proliferation without insulin resistance. Also it acts as a blood lipid regulator by regulating serum triglyceride levels and possibly by promoting ANGPTL3 cleavage. It interacts with ANGPTL3. It predominantly expressed in liver and also expressed in adipose tissues. The ability of the protein to induce pancreatic beta cell proliferation is promising in diabetes therapy. Betatrophin treatment could supply or replace insulin injections by increasing the number of insulin-producing cells in diabetes.

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