Recombinant Human NSE/ENO2 Protein

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£193.00

SKU:: RP02827
Additional Names:: 2-phospho-D-glycerate hydro-lyase|ENO2|Enolase 2|Gamma-enolase|Neural enolase|Neuron-specific enolase|NSE
Purity:: ≥ 80 %
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Met1-Leu434
Formulation:: Recombinant Human NSE/ENO2 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Leu434) of human NSE/ENO2 (Accession #NP_001966.1) fused with a 6xHis tag at the N-terminus.
Species:: Human
Sequence:: MSIEKIWAREILDSRGNPTVEVDLYTAKGLFRAAVPSGASTGIYEALELRDGDKQRYLGKGVLKAVDHINSTIAPALISSGLSVVEQEKLDNLMLELDGTENKSKFGANAILGVSLAVCKAGAAERELPLYRHIAQLAGNSDLILPVPAFNVINGGSHAGNKLAMQEFMILPVGAESFRDAMRLGAEVYHTLKGVIKDKYGKDATNVGDEGGFAPNILENSEALELVKEAIDKAGYTEKIVIGMDVAASEFYRDGKYDLDFKSPTDPSRYITGDQLGALYQDFVRDYPVVSIEDPFDQDDWAAWSKFTANVGIQIVGDDLTVTNPKRIERAVEEKACNCLLLKVNQIGSVTEAIQACKLAQENGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLMRIEEELGDEARFAGHNFRNPSVL
Uniprot:: P09104
Synonyms:: 2-phospho-D-glycerate hydro-lyase;2-phospho-D-glycerate hydrolyase;Enolase 2;enolase 2 (gamma, neuronal);epididymis secretory protein Li 279;gamma-enolase;HEL-S-279;neural enolase;neuron specific gamma enolase;neuron-specific enolase;neuronal enriched enolase;neurone-specific enolase;NSE
Extra Details:: Gamma-enolase, also known as Enolase 2, belongs to the enolase family. The alpha/alpha homodimer of ENO2 is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. During ontogenesis, there is a transition from the alpha/alpha homodimer to the alpha/beta heterodimer in striated muscle cells, and to the alpha/gamma heterodimer in nerve cells. Levels of ENO2 increase dramatically in cardiovascular accidents, cerebral trauma, brain tumors and Creutzfeldt-Jakob disease. ENO2 has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. It binds to cultured neocortical neurons and promotes cell survival in a calcium-dependent manner.

Shipping Conditions:: Blue Ice