Recombinant Human RNF43 Protein

Size

£353.00

SKU:: RP02777
Additional Names:: RNF124|SSPCS|URCC
Molecular Weight:: 55-60 kDa
Purity:: ≥ 95 % as determined by SDS-PAGE.≥ 95 %
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Gly24-Tyr197
Formulation:: Recombinant Human RNF43 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Tyr197) of human RNF43 (Accession #NP_001292473.1) fused with a hFc tag at the C-terminus.
Species:: Human
Sequence:: GFGRTGLVLAAAVESERSAEQKAIIRVIPLKMDPTGKLNLTLEGVFAGVAEITPAEGKLMQSHPLYLCNASDDDNLEPGFISIVKLESPRRAPRPCLSLASKARMAGERGASAVLFDITEDRAAAEQLQQPLGLTWPVVLIWGNDAEKLMEFVYKNQKAHVRIELKEPPAWPDY
Uniprot:: Q68DV7
Synonyms:: E3 ubiquitin-protein ligase RNF43;RING finger protein 43;RING-type E3 ubiquitin transferase RNF43;RNF124;SSPCS;URCC
Extra Details:: RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/B Beta-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.