Recombinant Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein

Size

POA

SKU:: RP02712
Additional Names:: Integrin alpha V beta 6|ITGAV&ITGB6
Molecular Weight:: 90-150 kDa
Purity:: ≥ 95 % as determined by Tris-Bis PAGE;≥ 95 %
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Phe31-Val992(ITGAV)&Gly22-Asn707(ITGB6)
Formulation:: Recombinant Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal.; It contains Phe31-Val992(ITGAV) acidic tail&Gly22-Asn707(ITGB6) basic tail.
Species:: Human
Uniprot:: P06756-1, P18564-1
Synonyms:: AI1H;antigen identified by monoclonal antibody L230;CD51;integrin alpha-V;integrin alphaVbeta3;integrin beta-6;integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51);integrin, beta 6;MSK8;Vitronectin receptor;vitronectin receptor subunit alpha;VNRA;VTNR
Extra Details:: ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion . ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 .