RP02708
Recombinant Human LILRA4/ILT-7/CD85g Protein
Size
£353.00
- SKU:
- RP02708
- Additional Names:
- CD85g|ILT-7|ILT7|ILT7MGC129598|LILRA4|MGC129597
- Molecular Weight:
- 60-75 kDa
- Purity:
- ≥ 95 % as determined by Tris-Bis PAGE;≥ 95 %
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Glu24-Asn446
- Formulation:
- Recombinant Human LILRA4/ILT-7/CD85g Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu24-Asn446) of Human LILRA4/ILT-7/CD85g (Accession #) fused with His tag and Avi tag at the C-terminal.
- Species:
- Human
- Uniprot:
- P59901
- Synonyms:
- CD85 antigen-like family member G;CD85g;ILT7;immunoglobulin-like transcript 7;leucocyte Ig-like receptor A4;leukocyte immunoglobulin-like receptor subfamily A member 4;leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4;leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 4
- Extra Details:
- LILRA4, also known as ILT7 and CD85g, is an approximately 60-70 kDa variably glycosylated transmembrane protein that regulates immune cell activation. Mature human LILRA4 consists of a 423 amino acid (aa) extracellular domain (ECD) with four immunoglobulin-like domains, a 21 aa transmembrane segment, and a 32 aa cytoplasmic domain.LILRA4 function coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades.
- Shipping Conditions:
- Blue Ice