RP02462B
Biotinylated Recombinant Human Notch 2 Protein
Size
£657.00
- SKU:
- RP02462B
- Additional Names:
- NOTCH2,AGS2,HJCYS,hN2,notch 2
- Molecular Weight:
- 70-80 kDa
- Purity:
- ≥ 95 % as determined by Tris-Bis PAGE;≥ 95 %
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Leu26-Gln530
- Formulation:
- Biotinylated Recombinant Human Notch 2 Protein is produced by Expi293 expression system. The target protein is expressed with sequence (Leu26-Gln530) of Human Notch 2 fused with a His tag and Avi tag at the C-terminal.
- Species:
- Human
- Uniprot:
- Q04721
- Synonyms:
- AGS2;HJCYS;hN2;neurogenic locus notch homolog protein 2;notch 2;Notch homolog 2
- Extra Details:
- Human Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch-2 is lethal, showing that not all functions overlap.Notch-2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
- Shipping Conditions:
- Blue Ice