RP02175
Recombinant Human GFER/ALR Protein
Size
£145.00
- SKU:
- RP02175
- Additional Names:
- GFER,ALR,ERV1,HERV1,HPO,HPO1,HPO2,HSS
- Molecular Weight:
- 15 kDa
- Purity:
- ≥90%
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Met1-Asp125
- Formulation:
- Recombinant Human GFER/ALR Protein is produced by E.coli expression system. The target protein is expressed with sequence (Met1-Asp125) of human GFER (Accession #P55789) fused with a 6xHis tag at the N-terminus.
- Species:
- Human
- Uniprot:
- P55789
- Synonyms:
- ALR;Augmenter of liver regeneration;ERV1;ERV1 homolog;erv1-like growth factor;FAD-linked sulfhydryl oxidase ALR;hepatic regenerative stimulation substance;Hepatopoietin;hepatopoietin protein;HERV1;HPO;HPO1;HPO2;HSS;MMCHD;MPMCD
- Extra Details:
- GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1/ALR family of proteins. GFER is widely expressed in various human tissues. They are two isoforms of this protein. Isoform 1 could regenerate the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2 may act as an autocrine hepatotrophic growth factor promoting liver regeneration. GFER could also induce the expression of S- adenosylmethionine decarboxyl-ase and ornithine decarboxylases (ODC). S-adenosylmethionine decarboxyl-ase and ornithine decarboxylases play an important role in the synthesis of polyamines.
- Shipping Conditions:
- Blue Ice