Recombinant Human Cathepsin E Protein

Size

£193.00

SKU:: RP02167
Additional Names:: CTSE,CATE
Molecular Weight:: 46 kDa
Purity:: ≥95%
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Ser20-Pro396
Formulation:: Recombinant Human Cathepsin E Protein is produced by Mammalian expression system. The target protein is expressed with sequence (Ser20-Pro396) of human CTSE (Accession #P14091) fused with a 6xHis tag at the C- terminus.
Species:: Human
Uniprot:: P14091
Synonyms:: CATE;cathepsin E;erythrocyte membrane aspartic proteinase;slow-moving proteinase
Extra Details:: Cathepsin E (CTSE) is a gastric aspartyl protease that functions as a disulfide-linked homodimer. It is a member of the Peptidase C1 family, and has a specificity similar to that of Pepsin A and Cathepsin D. CTSE is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome. It is expressed abundantly in the stomach, the Clara cells of the lung and activated B- lymphocytes, and at lower levels in lymph nodes, skin and spleen. CTSE is an intracellular proteinase that have a role in immune function, activation-induced lymphocyte depletion in the thymus, neuronal degeneration and glial cell activation in the brain. Futhermore, it probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation.