Recombinant Mouse Alkaline phosphatase,tissue-nonspecific isozyme/ALPL Protein

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£145.00

SKU:: RP01999
Additional Names:: Alpl, Akp-2, Akp2,Alkaline phosphatase, tissue-nonspecific isozyme, AP-TNAP, TNAP, TNSALP, EC:3.1.3.1, Alkaline phosphatase 2, Alkaline phosphatase liver/bone/kidney isozyme, Phosphoamidase, Phosphocreatine phosphatase, EC:3.9.1.1
Molecular Weight:: 66 -75kDa
Purity:: ≥90%
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Phe18-Ala500
Formulation:: Recombinant Mouse Alkaline phosphatase,tissue-nonspecific isozyme/ALPL Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe18-Ala500) of Mouse Alkaline phosphatase,tissue-nonspecific isozyme/ALPL (Accession #NP_001274101.1) fused with His at the C-terminus.
Species:: Mouse
Sequence:: FVPEKERDPSYWRQQAQETLKNALKLQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNTGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIKDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHKHSHYVWNRTELLALDPSRVDYLLGLFEPGDMQYELNRNNLTDPSLSEMVEVALRILTKNLKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDQAIGKAGAMTSQKDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMVSDTDKKPFTAILYGNGPGYKVVDGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFAKGPMAHLLHGVHEQNYIPHVMAYASCIGANLDHCAWA
Uniprot:: P09242
Synonyms:: Ak;Akp;Akp-2;Akp2;Alkaline phosphatase 2;alkaline phosphatase 2, liver;Alkaline phosphatase liver/bone/kidney isozyme;alkaline phosphatase, tissue-nonspecific isozyme;ALP;APTNAP;T;TNAP;TNSALP
Extra Details:: Several distinct genes encode alkaline phosphatases (APs) in mice with different tissue-specific expression patterns. The Alpl gene, also known as Akp2, encodes the liver/bone/kidney isozyme, also known as the tissue-nonspecific AP (TNAP). The Alpl gene is a key regulator of bone mineralization in mice . A variety of mutations in the human ALPL gene leads to different forms of hypophosphatasia, characterized by poorly mineralized cartilage and bones . The native ALPL is a glycosylated homodimer attached to the membrane through a GPI-anchor.

Shipping Conditions:: Blue Ice