Recombinant Human Gamma-glutamyl hydrolase/GGH Protein

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£145.00

SKU:: RP01957
Additional Names:: GGH,Gamma-glutamyl hydrolase, EC:3.4.19.9, Conjugase, GH, Gamma-Glu-X carboxypeptidase
Molecular Weight:: 30-35 kDa
Purity:: ≥95%
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Arg25-Asp318
Formulation:: Recombinant Human Gamma-glutamyl hydrolase/GGH Protein is produced by E. coli expression system. The target protein is expressed with sequence (Arg25-Asp318) of Human Gamma-glutamyl hydrolase/GGH (Accession #NP_003869.1) fused with a His tag at the N-terminus.
Species:: Human
Sequence:: RPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYGVQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQFSPIYTGNISSFQQCYIFD
Uniprot:: Q92820
Synonyms:: Conjugase;gamma-Glu-X carboxypeptidase;gamma-glutamyl hydrolase;gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase);GATD10;GH
Extra Details:: Gamma-glutamyl hydrolase/GGH regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. GGH is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. cytoplasmic GGH might play a relevant role in the development and progression of invasive breast cancer.

Shipping Conditions:: Blue Ice