Recombinant Human IFN-alpha 10 Protein

Size

£133.00

SKU:: RP01919
Additional Names:: IFN-alpha 10|IFN-alpha C|IFN-alpha-10|IFN-alphaC|IFNA10|IFNalpha C|interferon alpha-10|Interferon alpha-6L|Interferon alpha-C|interferon, alpha 10|LeIF C|MGC119878|MGC119879
Molecular Weight:: 20-25 kDa
Purity:: ≥90%
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Cys24-Asp189
Formulation:: Recombinant Human IFN-alpha 10 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys24-Asp189) of Human IFN-alpha 10/IFNA10 (Accession #NP_002162.1) fused with His tag at the C-terminus.
Species:: Human
Sequence:: CDLPQTHSLGNRRALILLGQMGRISPFSCLKDRHDFRIPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLEACVIQEVGVEETPLMNEDSILAVRKYFQRITLYLIERKYSPCAWEVVRAEIMRSLSFSTNLQKRLRRKD
Uniprot:: P01566
Synonyms:: IFN-alpha-10;IFN-alphaC;interferon alpha-10;interferon alpha-6L;interferon alpha-C;leIF C
Extra Details:: Interferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, classified based on their binding specificity to cell surface receptors . Human IFNA2 was originally cloned in the early '80s and now more than a dozen closely related IFN alpha subtypes have been identified in both the human and mouse genome, each sharing about 80% amino acid (aa) sequence homology. Structurally, type I IFNs belong to the class of five helicalbundle cytokines, with the IFNA subtypes containing 2 conserved disulfide bonds. Mature human IFNA10 shares 61% aa sequence identity with mouse IFNA7. The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 (alpha -subunit) and IFNAR2 (beta -subunit). Individual IFNA subtypes are known to display unique efficacies to viral protection, and IFNA10 has been shown to be a strong inducer of IFN-stimulated genes and antiviral protection. Additionally, IFNA10 exhibits weak antiviral effects against SARS-CoV-2 .

Shipping Conditions:: Blue Ice