Recombinant Mouse Neuropilin-1/NRP1/VEGF165R/CD304 Protein

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£133.00

SKU:: RP01869
Additional Names:: BDCA-4|BDCA4|CD304|CD304 antigen|DKFZp686A03134|DKFZp781F1414|neuropilin 1|Neuropilin-1|Neuropilin1|NP1|NRP|NRP1|transmembrane receptor|Vascular endothelial cell growth factor 165 receptor|VEGF165R
Molecular Weight:: 120-140 kDa
Purity:: ≥90%
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Phe22-Pro856
Formulation:: Recombinant Mouse Neuropilin-1/NRP1/VEGF165R/CD304 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe22-Pro856) of Mouse Neuropilin-1/NRP1/VEGF165R/CD304(Accession #NP_032763.2) fused with a His tag at the C-terminus.
Species:: Mouse
Sequence:: FRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGMFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGVLSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYKEWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWISLKEGNKAIIFQGNTNPTDVVLGVFSKPLITRFVRIKPVSWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQADRNWMPENIRLVTSRTGWALPPSPHPYTNEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKTIMDDSKRKAKSFEGNNNYDTPELRTFSPLSTRFIRIYPERATHSGLGLRMELLGCEVEAPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPTDLDKKNTEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDP
Uniprot:: P97333
Synonyms:: A5 protein;C530029I03;N;neuropilin-1;Neuropilin-1 precursor (A5 protein);NP;NP-1;NPN-1;Npn1;Nrp;transmembrane receptor
Extra Details:: Neuropilin-1 (Npn-1, previously neuropilin; also CD304 or BDCA4 in humans) is a 130140 kDa type I transmembrane (TM) glycoprotein that regulates axon guidance and angiogenesis. The full-length 923 amino acid (aa) mouse Npn-1 contains a 623 aa extracellular domain (ECD) that shares 98% aa identity with rat and 93% aa identity with human, equine, bovine and canine Npn-1 . The ECD contains two N-terminal CUB domains (termed a1a2), two domains with homology to coagulation factors V and VIII (b1b2) and a MAM (meprin) domain (c). At least one splice variant that diverges at aa 587 and lacks the TM domain has been sequenced . This form is potentially a soluble antagonist, based on results from human Npn-1 splice variants . The sema domains of Class III secreted semaphorins such as Sema3A bind Npn-1 a1a2 . Heparin, the heparin-binding forms of VEGF (VEGF165, VEGF-B and VEGF-E), PlGF (PlGF2), and the Cterminus of Sema3 bind the b1b2 region . Npn-1 and Npn-2 share 48% aa identity within the ECD and can form homo- and hetero-oligomers via interaction of their MAM domains . Neuropilins show partially overlapping expression in neuronal and endothelial cells during development. Both Neuropilins act as co-receptors with plexins, mainly plexin A3 and A4, to bind class III semaphorins that mediate axon repulsion . However, only Npn-1 binds Sema3A, and only Npn-2 binds Sema3F . Both are coreceptors with VEGF R2 (also called KDR or Flk-1) for VEGF165 binding . Sema3A signaling can be blocked by VEGF165, which has higher affinity for Npn-1 . Npn-1 is preferentially expressed in developing or remodeling arteries . Npn-1 is also expressed on dendritic cells and mediates DC-induced T cell proliferation .

Shipping Conditions:: Blue Ice