RP01835
Recombinant Mouse IL-31 Protein
Size
£145.00
- SKU:
- RP01835
- Additional Names:
- 1700013B14Rik|IL-31|Il-31; interleukin 31|il31
- Molecular Weight:
- 15-35 kDa
- Purity:
- ≥90%
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Thr24-Cys163
- Formulation:
- Recombinant Mouse IL-31 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr24-Cys163) of mouse IL-31 (Accession #NP_083870.1) fused with a 6xHis tag at the C-terminus.
- Species:
- Mouse
- Sequence:
- TCSLSFGAPISKEDLRTTIDLLKQESQDLYNNYSIKQASGMSADESIQLPCFSLDREALTNISVIIAHLEKVKVLSENTVDTSWVIRWLTNISCFNPLNLNISVPGNTDESYDCKVFVLTVLKQFSNCMAELQAKDNTTC
- Uniprot:
- Q6EAL8
- Synonyms:
- 1700013B14Rik;IL-31;interleukin-31
- Extra Details:
- IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. May function in skin immunity. IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells. IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor B Beta (OSMRB Beta) expressed in immune and epithelial cells. These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.
- Shipping Conditions:
- Blue Ice