Recombinant Human CD320 Protein

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£133.00

SKU:: RP01815
Additional Names:: 8D6|8D6A|CD320|sCD320|TCBLR|TCII-R|TCN2R
Molecular Weight:: 35-45 kDa
Purity:: ≥95%
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Ala31-Thr704
Formulation:: Recombinant Human CD320 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser36-Val231) of human CD320 (Accession #NP_057663.1) fused with a His tag at the C-terminus.
Species:: Human
Sequence:: SPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPVTLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGV
Uniprot:: Q9NPF0-1
Synonyms:: 8D6;8D6 antigen;8D6A;CD320 antigen;FDC-signaling molecule 8D6;FDC-SM-8D6;TCBLR;TCN2R;transcobalamin 2 receptor;transcobalamin receptor
Extra Details:: CD320 is a heavily glycosylated protein that is expressed as a noncovalent dimer in the kidney, placenta, liver, intestine, and secondary lymphoid organs (3 - 5). It functions as an endocytic receptor for circulating complexes of Cobalamin (Vitamin B12) and Transcobalamin II. In the immune system, CD320 is expressed by germinal center B cells and follicular dendritic cells (FDC) and provides a co-stimulatory signal to B cells during the germinal center reaction (2, 6 - 8). CD320 also cooperates with CD44 in promoting the development of B cell lymphomas.

Shipping Conditions:: Blue Ice