RP01813
Recombinant Human NBL1 Protein
Size
£127.00
- SKU:
- RP01813
- Additional Names:
- D1S1733E|DAN|DAND1|NB|NO3
- Molecular Weight:
- 60 kda
- Purity:
- ≥95%
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Ala17-Asp181
- Formulation:
- Recombinant Human NBL1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala17-Asp181) of human NBL1 (Accession #NP_002183.1) fused with a hFc tag at the C-terminus.
- Species:
- Human
- Sequence:
- AAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACLGQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSCQACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAED
- Uniprot:
- P41271-1
- Synonyms:
- D1S1733E;DAN;DAN domain family member 1;DAND1;differential screening-selected gene aberrant in neuroblastoma;NB;neuroblastoma 1, DAN family BMP antagonist;neuroblastoma candidate region, suppression of tumorigenicity 1;neuroblastoma suppressor of tumorigenicity 1;NO3;Protein N03;Zinc finger protein DAN
- Extra Details:
- The Dan (Differential screening-selected gene aberrative in neuroblastoma, also known as N03) gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in the vertebrates. It is a founding member of the DAN family of secreted proteins, acts as an inhibitor of cell cycle progression, and is closely involved in retinoic acid-induced neuroblastoma differentiation. There are at least five mammalian protein members in the evolutionarily conserved Dan family including DAN, Gremlin/DRM, Cer1 (Cerberus-related), Dante, and PRDC (protein related to DAN and Cerberus), and share the C-terminal cystine-knot motif. As a secreted glycoprotein, DAN is a member of a class of glycoproteins shown to be secreted inhibitors of the transforming growth factor-beta (TGF-beta) and bone morphogenic protein pathways. It binds to BMPs and preventing their interactions with signaling receptor complexes, and accordingly regulates the processes of embryonic development and tissue differentiation. DAN gene product may have an important role in the regulation of the entry of cells into the S phase. Besides, the DAN gene product possesses an ability to revert phenotypes of transformed rat fibroblasts and represents a candidate tumor suppressor gene for neuroblastoma.
- Shipping Conditions:
- Blue Ice