RP01792
Recombinant Human Beta-nerve growth factor/NGFB Protein
Size
£108.00
- SKU:
- RP01792
- Additional Names:
- Beta-NGF|HSAN5|NGFB
- Molecular Weight:
- 15-20 kDa
- Purity:
- ≥90%
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Ser122-Ala241
- Formulation:
- Recombinant Human Beta-nerve growth factor/NGFB Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser122-Ala241) of human NGF (Accession #NP_002497.2) fused with and a 6xHis tag at the C-terminus.
- Species:
- Human
- Uniprot:
- P01138
- Synonyms:
- beta-nerve growth factor;Beta-NGF;HSAN5;nerve growth factor (beta polypeptide);nerve growth factor, beta subunit;NGFB;pro-nerve growth factor long
- Extra Details:
- NGF is a well-characterized neurotropic protein that plays a critical role in the development of sympathetic and some sensory neurons in the peripheral nervous system. In addition, NGF can also act in the central nervous system as a trophic factor for basal forebrain cholinergic neurons. NGF has also been shown to have biological effects on non-neuronal tissues. NGF is mitogenic for a factor?dependent human erythroleukemic cell line, TF-1. NGF has been found to increase the number of mast cells in neonatal rats and to induce histamine release from peritoneal mast cells. NGF will enhance histamine release and strongly modulate the formation of lipid mediators by basophils in response to various stimuli. NGF will also induce the growth and differentiation of human B lymphocytes as well as suppress apoptosis of murine peritoneal neutrophils. These results, taken together, suggest that NGF is a pleiotropic cytokine which, in addition to its neurotropic activities, may have an important role in the regulation of the immune system.
- Shipping Conditions:
- Blue Ice