Recombinant human FGF-23 Protein

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£193.00

SKU:: RP01740
Additional Names:: ADHR|FGFN|HFTC2|HPDR2|HYPF|PHPTC
Molecular Weight:: 35 kDa
Purity:: ≥95%
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Tyr25-Ile251
Formulation:: Recombinant human FGF-23 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Tyr25-Ile251) of human FGF-23/Fibroblast growth factor 23 (Accession #NP_065689.1) fused witha 6xHis tag at the C-terminus.
Species:: Human
Sequence:: YPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGHVDGAPHQTIYSALMIRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQTLENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSRRNEIPLIHFNTPIPRRHTRSAEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRVNTHAGGTGPEGCRPFAKFI
Uniprot:: Q9GZV9
Synonyms:: ADHR;FGFN;fibroblast growth factor 23;HFTC2;HPDR2;HYPF;phosphatonin;PHPTC;tumor-derived hypophosphatemia inducing factor;Tumor-derived hypophosphatemia-inducing factor
Extra Details:: Fibroblast growth factor 23 (FGF23) is is an endocrine member of the family of FGFs and mainly produced in the bone and, upon secretion, forms a complex with a FGF receptor and coreceptor A AlphaKlotho. FGF23 can exert several endocrine functions, such as acting as a hormone on the kidney, stimulating phosphate excretion and suppressing formation of 1,25(OH)2D3, active vitamin D. Moreover, it has paracrine activities on several cell types, including neutrophils and hepatocytes. FGF23 and phosphate have been revealed to be factors relevant in cancer. FGF23 is particularly significant for those forms of cancer primarily affecting bone (e.g., multiple myeloma) or characterized by bone metastasis.

Shipping Conditions:: Blue Ice