Recombinant Mouse IL-13 Protein

Size

£163.00

SKU:: RP01596S
Additional Names:: Interleukin-13, IL-13, T-cell activation protein P600, Il13, Il-13
Molecular Weight:: 15-35 kDa
Purity:: ≥90%
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Gly21-Phe131
Formulation:: Recombinant Mouse IL-13 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly21-Phe131) of Mouse IL-13 (Accession #P20109) fused with a His at the N-terminus.
Species:: Mouse
Uniprot:: P20109
Synonyms:: Il-;Il-13;interleukin-13;T-cell activation protein P600
Extra Details:: Mouse interleukin 13 (mIL-13) is a pleiotropic cytokine produced by activated Th2 cells. IL-13 induces B cell proliferation and immunoglobin production. It contains a four helical bundle with two internal disulfide bonds. Mouse IL13 shares 58% sequence identity with human protein and exhibits cross-species activity. IL13 signals via receptor IL13R (type2, IL4R) and activates STAT-6. IL13 initially binds IL-13RA Alpha1 with low affinity and triggers association of IL4R A Alpha , generating a high affinity heterodimeric receptor IL13R and eliciting downstream signals. IL13 also binds IL-13RA Alpha2 with high affinity, which plays a role in a negative feedback system of IL13 signaling. IL13 is an important mediator of allergic inflammation and disease.