Recombinant Human IL-1 Rrp2/IL-1 R6 Protein

Size

£133.00

SKU:: RP01547
Additional Names:: IL1RL2,IL-1Rrp2,IL-36R,IL1R-rp2,IL1RRP2,IL36R
Molecular Weight:: 75-100 kDa
Purity:: ≥95%
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Asp20-Arg335
Formulation:: Recombinant Human IL-1 Rrp2/IL-1 R6 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp20-Arg335) of human IL-1 Rrp2/IL-1 R6 (Accession #NP_003845.2) fused with a hFc tag at the C-terminus.
Species:: Human
Sequence:: DGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNSSKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGERFTVLETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITERAGYGGSVPKIIYPKNHSIEVQLGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFR
Uniprot:: Q9HB29
Synonyms:: IL-1 receptor-related protein 2;IL-1Rrp2;IL-36 receptor;IL-36R;IL1R-rp2;IL1RRP2;interleukin-1 receptor-like 2;interleukin-1 receptor-related protein 2
Extra Details:: IL1RL2 (Interleukin 1 Receptor-Like 2, also known as IL-36R) is a Protein Coding gene. The protein encoded by this gene is a member of the interleukin 1 receptor family. This gene and four other interleukin 1 receptor family genes form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. The IL36 receptor is an important mediator molecule in the inflammatory response. Animal data suggest that IL1RL2 is involved in mucosal healing. Therapeutic intervention of IL-36R signaling offers an innovative treatment paradigm for targeting epithelial cell-mediated inflammatory diseases such as the life-threatening psoriasis variant called generalized pustular psoriasis (GPP). Diseases associated with IL1RL2 include Familial Cold Autoinflammatory Syndrome 2 and Geographic Tongue.

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