Recombinant Human REG-4 Protein

Size

£127.00

SKU:: RP01398
Additional Names:: REG4,GISP,REG-IV,RELP
Molecular Weight:: 15-25 kDa
Purity:: ≥95%
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Met1-Pro158
Formulation:: Recombinant Human REG-4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met 1-Pro 158) of human REG4 (Accession #NP_001152824.1) fused with a 6xHis tag at the C-terminus.
Species:: Human
Sequence:: MASRSMRLLLLLSCLAKTGVLGDIIMRPSCAPGWFYHKSNCYGYFRKLRNWSDAELECQSYGNGAHLASILSLKEASTIAEYISGYQRSQPIWIGLHDPQKRQQWQWIDGAMYLYRSWSGKSMGGNKHCAEMSSNNNFLTWSSNECNKRQHFLCKYRP
Uniprot:: Q9BYZ8-1
Synonyms:: gastrointestinal secretory protein;GISP;reg IV;REG-4;REG-IV;REG-like protein;regenerating gene type IV;regenerating islet-derived family, member 4;regenerating islet-derived protein 4;regenerating islet-derived protein IV;RELP
Extra Details:: Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, a member of the regenerating gene family belonging to the calcium (C-type) dependent lectin superfamily, has been found to be involved in malignancy in several different organs including the stomach, colorectum, pancreas and prostate. It is highly expressed in the gastrointestinal tract and markedly up-regulated in colon adenocarcinoma, pancreatic cancer, gastric adenocarcinoma, and inflammatory bowel disease. Expression of the Reg4 in different cell types has been associated with regeneration, cell growth and cell survival, cell adhesion and resistance to apoptosis. REG4 protein overexpression is associated with an unfavorable response to preoperative chemoradiotherapy and may be used as a predictive biomarker clinically. REG4 may play an important role in the development and progression of colorectal cancer, as well as in intestinal morphogenesis and epithelium restitution.

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