Recombinant Human IL-5 Protein

Size

£163.00

SKU:: RP01316
Additional Names:: IL5,EDF,IL-5,TRF
Molecular Weight:: 18-20 kDa
Purity:: ≥95%
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Ile20-Ser134
Formulation:: Recombinant Human IL-5 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile20-Ser134) of human IL-5 (Accession #NP_000870.1) fused with an 6xHis tag at the C-terminus.
Species:: Human
Sequence:: IPTEIPTSALVKETLALLSTHRTLLIANETLRIPVPVHKNHQLCTEEIFQGIGTLESQTVQGGTVERLFKNLSLIKKYIDGQKKKCGEERRRVNQFLDYLQEFLGVMNTEWIIES
Uniprot:: P05113
Synonyms:: B-cell differentiation factor I;colony-stimulating factor, eosinophil;EDF;eosinophil differentiation factor;IL-5;interleukin-5;T-cell replacing factor;TRF
Extra Details:: Interleukin 5 (IL-5) is a member of the interleukin family with a length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered a key mediator in eosinophil activation. Interleukin 5 (IL-5) has long been associated with several allergic diseases, including allergic rhinitis and asthma. Growth in the number of circulating, airway tissue, and induced sputum eosinophils have been observed in patients with these diseases. IL-5 also had something with the terminally differentiated granulocyte eosinophils. IL-5 was originally found as an eosinophil colony-stimulating factor. It has been proved to be a major regulator of eosinophil accumulation in tissues and can modulate eosinophil behavior at every stage from maturation to survival.

Shipping Conditions:: Blue Ice