RP00815
Recombinant Human Estrogen receptor/ESR1 Protein
Size
£193.00
- SKU:
- RP00815
- Additional Names:
- ER, ESR, ESRA, ESTRR, Era, NR3A1,ESR1,ESRA Alpha,ESR,ESRA,ESTRR,Era,NR3A1,ER alpha
- Molecular Weight:
- 14 kDa
- Purity:
- ≥95%
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Met1-Gln116
- Formulation:
- Recombinant Human Estrogen receptor/ESR1 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Gln116) of human Estrogen Receptor (Accession #P03372) fused with a 6xHis tag at the N-terminus.
- Species:
- Human
- Sequence:
- MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQ
- Uniprot:
- P03372
- Synonyms:
- E2 receptor alpha;ER;ER-alpha;Era;ESR;ESRA;estradiol receptor;estrogen nuclear receptor alpha;estrogen receptor;estrogen receptor alpha E1-E2-1-2;estrogen receptor alpha E1-N2-E2-1-2;ESTRR;NR3A1;nuclear receptor subfamily 3 group A member 1;oestrogen receptor alpha
- Extra Details:
- Estrogen Receptor is a major ligand---activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but they also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
- Shipping Conditions:
- Blue Ice