Recombinant Human Mature BMP-10 Protein

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£223.00

SKU:: RP00771
Additional Names:: BMP10,Bone morphogenetic protein 10, BMP-10
Molecular Weight:: 10-20 KDa
Purity:: ≥90%
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Ser22-Arg424
Formulation:: Recombinant Human Mature BMP-10 Protein is produced by HEK293 cells system. The target protein is expressed with sequence (Ser22-Arg424) of Human Mature BMP-10(Accession #NP_055297.1) fused with No Tag.
Species:: Human
Sequence:: SPIMNLEQSPLEEDMSLFGDVFSEQDGVDFNTLLQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLFSQPVSFNGLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLESKGDNEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGSSTHQLEVHIESKHDEAEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLDSFSSGPGEEALLQMRSNIIYDSTARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGCR
Uniprot:: O95393
Synonyms:: bone morphogenetic protein 10
Extra Details:: BMP-10 is critical for the proper development of the heart but is not expressed until after cardiac patterning or looping are completed. BMP-10 production appears at the onset of trabeculation and chamber formation and is restricted to the right atrium in the adult heart . Homozygous BMP-10 knockout mice die in utero due to arrested cardiac development. BMP-10 is required for the expression of the cardiogenic transcription factors NKX2.5 and MEF2C in developing myocardium and the growth of embryonic cardiomyocytes. NKX2.5 itself negatively regulates BMP-10 expression in cardiac myocytes. Multiple human congenital heart defects result from mutations in NKX2.5 and require BMP-10 expression . In mice, genetic knockout of ErbB leads to a similar phenotype but appears not to involve BMP-10, and knockout of the calcium channel subunit FKBP12 induces BMP-10 over-expression. BMP-10 in the postnatal heart promotes increased cardiomyocyte and heart size. BMP-10 has been shown to signal through ALK-1, BMPR-IA, BMPR-IB, and BMPR-II in transfectants and non-cardiac cell lines . A functional BMP-10 receptor in the heart has not yet been identified, although deletion of BMPR-IA causes similar cardiac morphogenetic abnormalities. In dermal endothelial cells, BMP-10 induces migration, proliferation, and gene expression typically associated with ALK-1.

Shipping Conditions:: Blue Ice