Recombinant Human LGR5 / GPR49 protein

Size

£145.00

SKU:: RP00730
Additional Names:: LGR5, GPR49, GPR67,Leucine-rich repeat-containing G-protein coupled receptor 5
Molecular Weight:: 60-80 kDa
Purity:: ≥90%
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Gly22-Arg561
Formulation:: Recombinant Human LGR5 / GPR49 protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly 22 - Arg 561) of Human LGR5 / GPR49(Accession #NM_003667.3) fused with His tag at the C-terminus.
Species:: Human
Sequence:: GSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLTGNHALQSLISSENFPELKVIEMPYAYQCCAFGVCENAYKISNQWNKGDNSSMDDLHKKDAGMFQAQDERDLEDFLLDFEEDLKALHSVQCSPSPGPFKPCEHLLDGWLIR
Uniprot:: O75473-1
Synonyms:: FEX;G-protein coupled receptor 49;G-protein coupled receptor 67;G-protein coupled receptor HG38;GPR49;GPR67;GRP49;HG38;leucine-rich repeat-containing G-protein coupled receptor 5;orphan G protein-coupled receptor HG38
Extra Details:: LGR5 (also known as GPR49) is a seven-transmembrane protein of the class A Rhodopsin-like family of GPCRs. LGR5 and LGR4 bind the R-spondins with high affinity and mediate the potentiation of Wnt/B Beta-catenin signaling by enhancing Wnt-induced LRP6 phosphorylation. The LGR5/RSPO complex could promote Wnt signalling via the neutralization of two transmembrane E3 ligases, RNF43 and ZNRF3.

Shipping Conditions:: Blue Ice