RP00710
Recombinant Mouse Fc gamma RI/FCGR1/CD64 Protein
Size
£145.00
- SKU:
- RP00710
- Additional Names:
- High affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I, Fc-gamma RI, FcRI, CD64, Fcgr1
- Molecular Weight:
- 40-60 kDa
- Purity:
- ≥95%
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Glu25-Pro297
- Formulation:
- Recombinant Mouse Fc gamma RI/FCGR1/CD64 Protein is produced by Human Cells expression system. The target protein is expressed with sequence (Glu25-Pro297) of mouse Fc G Gamma RI/FCGR1A/CD64 (Accession #P26151) fused with a 6xHis tag at the C-terminus.
- Species:
- Mouse
- Sequence:
- EVVNATKAVITLQPPWVSIFQKENVTLWCEGPHLPGDSSTQWFINGTAVQISTPSYSIPEASFQDSGEYRCQIGSSMPSDPVQLQIHNDWLLLQASRRVLTEGEPLALRCHGWKNKLVYNVVFYRNGKSFQFSSDSEVAILKTNLSHSGIYHCSGTGRHRYTSAGVSITVKELFTTPVLRASVSSPFPEGSLVTLNCETNLLLQRPGLQLHFSFYVGSKILEYRNTSSEYHIARAEREDAGFYWCEVATEDSSVL
- Uniprot:
- P26151
- Synonyms:
- AI323638;AV092959;CD64;fc-gamma RI;Fcgam;FcgammaRI;fcRI;high affinity immunoglobulin gamma Fc receptor I;igG Fc receptor I;IgG high affinity Fc receptor;IGGHAFC
- Extra Details:
- CD64, also known as Fc-gamma receptor 1 (Fc G Gamma RI), is a type of integral membrane glycoprotein that bindsmonomeric IgG-type antibodies with high affinity. After binding IgG, CD64 interacts with an accessory chainknown as the common G Gamma chain (G Gamma chain), which possesses an ITAM motif that is necessary for triggering cellularactivation. CD64 is composed of a signal peptide, three extracellular immunoglobulin domains of the C2-typeused to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 mediatesendocytosis, phagocytosis, antibody-dependent cellular cytotoxicity, cytokine release, and superoxideproduction. It is normally expressed on the surfaces of monocytes and macrophages.
- Shipping Conditions:
- Blue Ice