RP00670
Recombinant Pig CSF-1/M-CSF Protein
Size
£193.00
- SKU:
- RP00670
- Additional Names:
- Macrophage colony-stimulating factor 1, CSF-1, MCSF,CSF1,Porcine,Pig
- Molecular Weight:
- 45-60 KDa
- Species Reactivity:
- Porcine
- Purity:
- ≥95%
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Ser36-Arg189
- Formulation:
- Recombinant Pig CSF-1/M-CSF Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser36-Arg189) of Pig CSF-1/M-CSF (Accession #NP_001231452.1) fused with Fc tag at the C-terminus.
- Species:
- Porcine
- Synonyms:
- colony stimulating factor 1 (macrophage);macrophage colony stimulating factor alpha;macrophage colony stimulating factor beta;macrophage colony-stimulating factor 1;MCSF alpha;MCSFBETA
- Extra Details:
- Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.
- Shipping Conditions:
- Blue Ice