Recombinant Human IL-31 Protein

Size

£431.00

SKU:: RP00634
Additional Names:: IL-31|IL31|Interleukin-31
Molecular Weight:: 20-25 kDa
Purity:: ≥ 95 % as determined by SDS-PAGE;≥ 95 %
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Ser24-Thr164
Formulation:: Recombinant Human IL-31 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser24-Thr164) of Human IL-31 (Accession #Q6EBC2-1) fused with a N-His tag at the N-terminus.
Species:: Human
Sequence:: SHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT
Uniprot:: Q6EBC2-1
Synonyms:: IL-31;interleukin-31
Extra Details:: Many autoimmune skin diseases, such as bullous pemphigoid (BP), psoriasis and certain types of chronic urticaria, are associated with intensive pruritus. While histamine and neuropeptides have previously been ascribed to play a role in itch that accompanies these diseases, recent evidence suggests that the pruritogenic cytokine interleukin (IL)-31 is a major driver of pruritic responses. IL-31 was originally shown to be produced by activated helper T cells, particularly Th2 cells, mast cells, macrophages and dendritic cells.