Recombinant Human B7-H2/ICOSLG/CD275 Protein

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£133.00

SKU:: RP00385
Additional Names:: ICOSLG,B7-H2,B7H2,B7RP-1,B7RP1,CD275,GL50,ICOS-L,ICOSL,LICOS
Molecular Weight:: 70-100 kDa
Purity:: ≥95%
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Asp19-Thr256
Formulation:: Recombinant Human B7-H2/ICOSLG/CD275 Protein is produced by Human Cell expression system. The target protein is expressed with sequence (Asp19-Ser258) of human ICOSLG/B7-H2/CD275 (Accession #O75144) fused with a 6xHis tag at the C-terminus.
Species:: Human
Sequence:: DTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESKTVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSLGFQEVLSVEVTLHVAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLLDQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERDKITENPVSTGEKNAAT
Uniprot:: O75144
Synonyms:: B7 homolog 2;B7 homologue 2;B7-H2;B7-like protein Gl50;B7-related protein 1;B7h;B7H2;B7RP-1;B7RP1;CD275;GL50;ICOS ligand;ICOS-L;ICOSL;LICOS;transmembrane protein B7-H2 ICOS ligand
Extra Details:: Inducible co-stimulator ligand (ICOSL) is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.

Shipping Conditions:: Blue Ice