Recombinant Human CD2 Protein

Size

£163.00

SKU:: RP00241
Additional Names:: CD2,LFA-2,SRBC,T11
Molecular Weight:: 35-40 kDa
Purity:: ≥95%
Storage Conditions:: -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
Supplier:: Abclonal
Immunogen:: Lys25-Asp209
Formulation:: Recombinant Human CD2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys 25 - Asp 209 ) of human CD2 (Accession #NP_001758.2) fused with a 6xHis tag at the C-terminus.
Species:: Human
Sequence:: KEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLD
Uniprot:: P06729
Synonyms:: CD2 antigen (p50), sheep red blood cell receptor;erythrocyte receptor;LFA-2;LFA-3 receptor;lymphocyte-function antigen-2;rosette receptor;SRBC;T-cell surface antigen CD2;T-cell surface antigen T11/Leu-5;T11
Extra Details:: T-cell surface antigen CD2, also known as T-cell surface antigen T11/Leu-5, and SRBC, is a single-pass type I membrane protein. It contains one Ig-like C2-type domain and one Ig-like V-type domain. CD2 is a cell adhesion molecule expressed on T cells and is recognized as a target for CD48 (rats) and CD58 (humans). Further, intracellular CD2 signaling pathways and networks are being discovered by the identification of several cytosolic tail binding proteins. CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain of CD2 is implicated in the signaling function. The complex of CD2 and CD58 also plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. As a cell surface glycoprotein, CD2 expressed on most human T cells and natural killer (NK) cells and plays an important role in mediating cell adhesion in both T-lymphocytes and in signal transduction.

Shipping Conditions:: Blue Ice