RP00005
Recombinant Human MANF Protein
Size
£127.00
- SKU:
- RP00005
- Additional Names:
- MANF,ARMET,ARP
- Molecular Weight:
- Approximately 18 kDa
- Purity:
- ≥95%
- Storage Conditions:
- -20[o]C reconstituted. Avoid freeze/thaw cycles., 2-8[o]C reconstituted., -20[o]C/-70[o]C lyophilized. Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Leu25-Leu182
- Formulation:
- Recombinant Human MANF Protein is produced by E. coli expression system. The target protein is expressed with sequence (Leu25-Leu182) of human MANF (Accession #NP_006001.4).
- Species:
- Human
- Sequence:
- LRPGDCEVCISYLGRFYQDLKDRDVTFSPATIENELIKFCREARGKENRLCYYIGATDDAATKIINEVSKPLAHHIPVEKICEKLKKKDSQICELKYDKQIDLSTVDLKKLRVKELKKILDDWGETCKGCAEKSDYIRKINELMPKYAPKAASARTDL
- Uniprot:
- P55145
- Synonyms:
- Arginine-rich protein;arginine-rich, mutated in early stage tumors;ARMET;ARP;mesencephalic astrocyte-derived neurotrophic factor;Protein ARMET
- Extra Details:
- The protein is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this protein increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in Normal tissues and are thus no longer thought to be tumor-related.
- Shipping Conditions:
- Blue Ice