RMK0307
Rabbit anti-Mouse GM-CSF monoclonal antibody
Size
£372.30
Was £438.00
- SKU:
- RMK0307
- Application:
- ELISA
- Species Reactivity:
- Mouse
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Abclonal
- Immunogen:
- Recombinant fusion protein containing a sequence corresponding to amino acids 18-141 of mouse GM-CSF (NP_034099.2).
- Formulation:
- Supplied as a 0.2um filtered solution in PBS with 0.05%ProClin 300,PH 7.4.
- Species:
- Mouse
- Uniprot:
- P01587
- Synonyms:
- colony stimulating factor 2 (granulocyte-macrophage);colony-stimulating factor;CSF;Csfg;Csfgm;Gm-CS;Gm-CSf;GMCS;GMCSF;granulocyte macrophage-colony stimulating factor;granulocyte-macrophage colony stimulating factor 2;granulocyte-macrophage colony-stimulating factor;MGI-I;MGI-IGM;molgramostim;molgramostin;put. GM-CSF;sargramostim
- Extra Details:
- GM-CSF was initially characterized as a factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM-CSF is produced by a number of different cell types (including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes) in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils . GM-CSF promotes a Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity . It shows clinical effectiveness in ameliorating chemotherapy-induced neutropenia, and GM-CSF transfected tumor cells are utilized as cancer vaccines . The 22 kDa glycosylated GM-CSF, similar to IL-3 and IL-5, is a cytokine with a core of four bundled alpha -helices. Mature mouse GM-CSF shares 49%-54% amino acid sequence identity with canine, feline, human, and porcine GM-CSF and 69% with rat GM-CSF. GM-CSF exerts its biological effects through a heterodimeric receptor complex composed of GM-CSF R alpha /CD116 and the signal transducing common beta chain (CD131) which is also a component of the high-affinity receptors for IL-3 and IL-5. In addition, GM-CSF binds a naturally occurring soluble form of GM-CSF R alpha . The activity of GM-CSF is species specific between human and mouse. Mouse GM-CSF is only weakly active on rat cells, although rat GM-CSF is fully active on mouse cells .lthough rat GM-CSF is fully active on mouse cells .locytes, macrophages, eosinophils and erythrocytes.
- Shipping Conditions:
- Dry Ice