RMK0112
Rabbit anti-Mouse G-CSF monoclonal antibody (DET)
Size
£347.65
Was £409.00
- SKU:
- RMK0112
- Additional Names:
- Csfg|G-CSF|MGI-IG
- Application:
- ELISA
- Species Reactivity:
- Mouse
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Abclonal
- Immunogen:
- Recombinant mouse G-CSF
- Formulation:
- Supplied as a 0.2um filtered solution in PBS with 0.05%ProClin 300,PH 7.4.
- Species:
- Mouse
- Uniprot:
- P09920
- Synonyms:
- C17orf33;Csf;CSF3OS;Csfg;filgrastim;G-CS;G-CSF;GCSF;granulocyte colony-stimulating factor;granulocyte-colony stimulating factor;lenograstim;MGI-;MGI-IG;pluripoietin
- Extra Details:
- Mouse granulocyte-colony stimulating factor (G-CSF) is a 24-25 kDa monomeric glycoprotein that regulates the proliferation, differentiation and activation of hematopoietic cells. Mouse G-CSF cDNA encodes a 208 amino acid (aa) precursor protein with a 30 aa signal sequence that is proteolytically cleaved to form a 178 aa O-glycosylated mature protein containing two intrachain disulfide bridges. In humans, two distinct cDNA clones, encoding a 204 aa form and a minor alternatively spliced 207 aa form of G-CSF precursors, have been isolated.Mouse and human G-CSF are 76% identical at the aa sequence level and the two proteins show species cross-reactivity. G-CSF is produced primarily by monocytes and macrophages upon activation by endotoxin, TNF-A Alpha or IL-1. Other cell types, including fibroblasts, endothelial cells, astrocytes and bone marrow stroma cells, can also secrete G-CSF after activation. In addition, various tumor cells express G-CSF constitutively.
- Shipping Conditions:
- Dry Ice