Rabbit anti-Mouse G-CSF monoclonal antibody (CAP)

Size

£347.65

Was £409.00

SKU:: RMK0111
Additional Names:: Csfg|G-CSF|MGI-IG
Application:: ELISA
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C
Supplier:: Abclonal
Reactivities:: Mouse
Immunogen:: Recombinant mouse G-CSF
Formulation:: Supplied as a 0.2 um filtered solution in PBS with 0.05% Proclin 300, PH 7.4.
Species:: Human
Uniprot:: P09920
Synonyms:: Csf;Csfg;G-CS;G-CSF;granulocyte colony-stimulating factor;MGI-;MGI-IG
Extra Details:: Mouse granulocyte-colony stimulating factor (G-CSF) is a 24-25 kDa monomeric glycoprotein that regulates the proliferation, differentiation and activation of hematopoietic cells. Mouse G-CSF cDNA encodes a 208 amino acid (aa) precursor protein with a 30 aa signal sequence that is proteolytically cleaved to form a 178 aa O-glycosylated mature protein containing two intrachain disulfide bridges. In humans, two distinct cDNA clones, encoding a 204 aa form and a minor alternatively spliced 207 aa form of G-CSF precursors, have been isolated.Mouse and human G-CSF are 76% identical at the aa sequence level and the two proteins show species cross-reactivity. G-CSF is produced primarily by monocytes and macrophages upon activation by endotoxin, TNF-A Alpha or IL-1. Other cell types, including fibroblasts, endothelial cells, astrocytes and bone marrow stroma cells, can also secrete G-CSF after activation. In addition, various tumor cells express G-CSF constitutively.