Rabbit anti-Human GM-CSF monoclonal antibody(CAP)

Size

£347.65

Was £409.00

SKU:: RMK0105
Additional Names:: CSF|GMCSF
Application:: ELISA
Species Reactivity:: Human
Purification:: Affinity Purified
Storage Conditions:: -20[o]C
Supplier:: Abclonal
Reactivities:: Human, Mouse
Immunogen:: Recombinant Human GM-CSF Protein
Formulation:: Supplied as a 0.2 um filtered solution in PBS with 0.05% Proclin 300, pH 7.3.
Species:: Human
Uniprot:: P04141
Synonyms:: colony stimulating factor 2 (granulocyte-macrophage);Colony-stimulating factor;CSF;GMCSF;granulocyte macrophage-colony stimulating factor;granulocyte-macrophage colony-stimulating factor;molgramostim;molgramostin;sargramostim
Extra Details:: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. This gene plays a role in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been detected in SARS-CoV-2 infected patients that develop acute respiratory distress syndrome. Mice deficient in this gene or its receptor develop pulmonary alveolar proteinosis.