RMK0089
Rabbit anti-Human IL-12p70 monoclonal antibody (CAP)
Size
£347.65
Was £409.00
- SKU:
- RMK0089
- Application:
- CLIA
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Abclonal
- Immunogen:
- Recombinant Human IL-12p70 Protein
- Formulation:
- Supplied as a 0.2um filtered solution in PBS with 0.05% Proclin300, PH 7.4.
- Species:
- Human
- Uniprot:
- P29459, P29460
- Synonyms:
- CLMF;CLMF p35;CLMF p40;CLMF2;cytotoxic lymphocyte maturation factor 1, p35;cytotoxic lymphocyte maturation factor 35 kDa subunit;cytotoxic lymphocyte maturation factor 40 kDa subunit;IL-12 subunit p35;IL-12 subunit p40;IL-12, subunit p35;IL-12A;IL-12B;IL12, subunit p40;IL35 subunit;IMD28;IMD29;interleukin 12, p35;interleukin 12, p40;interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35);interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40);interleukin-12 alpha chain;interleukin-12 beta chain;interleukin-12 subunit alpha;interleukin-12 subunit beta;natural killer cell stimulatory factor, 40 kD subunit;NF cell stimulatory factor chain 1;NFSK;NK cell stimulatory factor chain 1;NK cell stimulatory factor chain 2;NKSF;NKSF1;NKSF2;P35
- Extra Details:
- Interleukin 12, also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a pleiotropic cytokine originally identified in the medium of activated human B lymphoblastoid cell lines. Biologically active IL-12 is a disulfide-linked, 70 kDa (p70) heterodimeric glycoprotein composed of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit.The p40 subunit of IL-12 has been shown to have extensive amino acid sequence homology to the extracellular domain of the human IL-6 receptor while the p35 subunit shows distant but significant sequence similarity to IL-6, G-CSF, and chicken MGF. These observations have led to the suggestion that IL-12 might have evolved from a cytokine/soluble receptor complex. Human and murine IL-12 share 70% and 60% amino acid sequence homology in their p40 and p35 subunits, respectively. IL-12 apparently shows species specificity with human IL-12 reportedly showing minimal activity in the murine system. IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and natural killer (NK) cells. These effects include inducing production of IFN-gamma and TNF by resting and activated T and NK cells, synergizing with other IFN-gamma inducers at both the transcriptional and post-transcriptional levels. This interaction induces IFN-gamma gene expression, enhancing the cytotoxic activity of resting NK and T cells, inducing and synergizing with IL-2 in the generation of lymphokine-activated killer (LAK) cells, acting as a co-mitogen to stimulate proliferation of resting T cells, and inducing proliferation of activated T and NK cells. Current evidence indicates that IL-12, produced by macrophages in response to infectious agents, is a central mediator of the cell-mediated immune response by its actions on the development, proliferation, and activities of TH1 cells. In its role as the initiator of cell-mediated immunity, it has been suggested that IL-12 has therapeutic potential as a stimulator of cell-mediated immune responses to microbial pathogens, metastatic cancers, and viral infections such as AIDS
- Shipping Conditions:
- Dry Ice