RMK0028
Rabbit anti-Human cTnI monoclonal antibody(CAP)
Size
£347.65
Was £409.00
- SKU:
- RMK0028
- Additional Names:
- CMD1FF|CMD2A|CMH7|cTnI|RCM1|TNNC1
- Application:
- CLIA
- Species Reactivity:
- Human
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Abclonal
- Immunogen:
- Synthetic peptide corresponding to human cTnI
- Formulation:
- Supplied as a 0.2 um filtered solution in PBS with 0.05% Proclin 300, pH 7.3.
- Species:
- Human
- Uniprot:
- P19429
- Synonyms:
- Cardiac troponin I;cardiomyopathy, dilated 2A (autosomal recessive);CMD1FF;CMD2A;CMH7;cTnI;RCM1;TNNC1;troponin I type 3 (cardiac);troponin I, cardiac muscle
- Extra Details:
- Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.
- Shipping Conditions:
- Dry Ice