RM18034
Rabbit anti-Human uPAR monoclonal antibody
Size
£347.65
Was £409.00
- SKU:
- RM18034
- Additional Names:
- CD87|U-PAR|UPAR|URKR
- Application:
- ELISA
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Abclonal
- Immunogen:
- Recombinant Human uPAR
- Formulation:
- Supplied as a 0.2 um filtered solution in PBS with 0.05% Proclin 300, pH 7.4.
- Uniprot:
- Q03405
- Synonyms:
- CD87;monocyte activation antigen Mo3;U-PAR;u-plasminogen activator receptor form 2;UPAR;URKR;urokinase plasminogen activator surface receptor;urokinase-type plasminogen activator (uPA) receptor
- Extra Details:
- This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined.
- Shipping Conditions:
- Dry Ice