RM17835
Rabbit anti-Chicken IL-10 monoclonal antibody (CAP)
Size
£372.30
Was £438.00
- SKU:
- RM17835
- Application:
- ELISA
- Species Reactivity:
- Avian
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C
- Supplier:
- Abclonal
- Reactivities:
- Avian
- Immunogen:
- Recombinant Chicken IL-10 Protein
- Formulation:
- Supplied as a 0.2 um filtered solution in PBS with 0.05% Proclin 300, pH 7.4.
- Species:
- Avian
- Uniprot:
- Q6A2H4
- Synonyms:
- IL-10;interleukin-10
- Extra Details:
- Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha. Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation
- Shipping Conditions:
- Dry Ice