RM17804
Rabbit anti-Sheep IL-6 monoclonal antibody(CAP)
Size
£372.30
Was £438.00
- SKU:
- RM17804
- Application:
- ELISA
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Abclonal
- Immunogen:
- Recombinant Sheep IL-6
- Formulation:
- Supplied as a 0.2um filtered solution in PBS with 0.05%ProClin 300,PH 7.4.
- Synonyms:
- IL-6;interleukin 6 (interferon, beta 2);interleukin-6
- Extra Details:
- Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.By Similarity IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology.
- Shipping Conditions:
- Dry Ice